The role of mutations associated with familial neurodegenerative disorders on blood–brain barrier function in an iPSC model

Table 1 Description of iPS cell lines

Cell line	Disease	Mutation	Gender	Age isolated	Source tissue	Reprogramming method	Source
BC1	Healthy	N/A	M	36	Bone marrow CD34 + cell	Episomal, OCT4, SOX2, KLF4, c-MYC and LIN28	[46]
WT2	Healthy	N/A	F	56	Dermal fibroblast	Episomal, OCT4, SOX2, NANOG, LIN28, MYC, KLF4	[28]
iPS12	Healthy	N/A	F	Cord blood	Mesenchymal stromal cell	Episomal OCT4, SOX2, KLF4, L-MYC	Alstem
SODA4 V	ALS	SOD1 A4 V	F	57	Dermal fibroblast	Retroviral, Sox2, Oct4, Klf4, c-Myc	[47]
JH033	ALS	C9orf72 expansion	M	65	Dermal fibroblast	Retroviral, Sox2, Oct4, Klf4, c-Myc	[47]
SCNA1	PD	SCNA1 A53T	F	51	Fibroblast	Episomal	NINDS cell repository (NN0000052)
SCNAT	PD	SCNA1 triplication	F	55	Fibroblast	Episomal	NINDS cell repository (NN0000049)
AD10	AD	PSEN1 A246E	F	56	Dermal fibroblast	Episomal, OCT4, SOX2, NANOG, LIN28, MYC, KLF4	[28]
AD6	AD	PSEN1 A246E	F	56	Dermal fibroblast	Episomal, OCT4, SOX2, NANOG, LIN28, MYC, KLF4	[28]
HD 71	HD	HTT CAG:71	F	Unknown	Fibroblast	Episomal	NINDS cell repository (NN0003949)
HD 50	HD	HTT CAG:50	F	37	Fibroblast	Episomal, OCT4, SOX2, KLF4, L-MYC, LIN28	NINDS cell repository (NN0003930)

ALS amyotrophic lateral sclerosis, PD Parkinson’s disease, AD Alzheimer’s disease, HD Huntington’s disease

ISSN: 2045-8118