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Table 1 Description of iPS cell lines

From: The role of mutations associated with familial neurodegenerative disorders on blood–brain barrier function in an iPSC model

Cell line Disease Mutation Gender Age isolated Source tissue Reprogramming method Source
BC1 Healthy N/A M 36 Bone marrow CD34 + cell Episomal, OCT4, SOX2, KLF4, c-MYC and LIN28 [46]
WT2 Healthy N/A F 56 Dermal fibroblast Episomal, OCT4, SOX2, NANOG, LIN28, MYC, KLF4 [28]
iPS12 Healthy N/A F Cord blood Mesenchymal stromal cell Episomal OCT4, SOX2, KLF4, L-MYC Alstem
SODA4 V ALS SOD1 A4 V F 57 Dermal fibroblast Retroviral, Sox2, Oct4, Klf4, c-Myc [47]
JH033 ALS C9orf72 expansion M 65 Dermal fibroblast Retroviral, Sox2, Oct4, Klf4, c-Myc [47]
SCNA1 PD SCNA1 A53T F 51 Fibroblast Episomal NINDS cell repository (NN0000052)
SCNAT PD SCNA1 triplication F 55 Fibroblast Episomal NINDS cell repository (NN0000049)
AD10 AD PSEN1 A246E F 56 Dermal fibroblast Episomal, OCT4, SOX2, NANOG, LIN28, MYC, KLF4 [28]
AD6 AD PSEN1 A246E F 56 Dermal fibroblast Episomal, OCT4, SOX2, NANOG, LIN28, MYC, KLF4 [28]
HD 71 HD HTT CAG:71 F Unknown Fibroblast Episomal NINDS cell repository (NN0003949)
HD 50 HD HTT CAG:50 F 37 Fibroblast Episomal, OCT4, SOX2, KLF4, L-MYC, LIN28 NINDS cell repository (NN0003930)
  1. ALS amyotrophic lateral sclerosis, PD Parkinson’s disease, AD Alzheimer’s disease, HD Huntington’s disease