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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: The role of mutations associated with familial neurodegenerative disorders on blood–brain barrier function in an iPSC model

Fig. 5

Cluster analysis demonstrates a phenotypical difference between healthy controls to NDD lines. This heatmap demonstrates the percentage of measurements in from each cell line within each cluster. Analysis is based on 599 measurements (TEER, Lucifer yellow permeability, glucose permeability, and Rhodamine efflux ratio): BC1 (N = 41), WT2 (N = 64), iPS12 (N = 53), JH033 (N = 52), SODA4V (N = 60), SCNA1 (N = 56), SCNAT (N = 81), AD6 (N = 69), AD10 (N = 52), HD50 (N = 57), and HD71 (N = 64). Rows are sorted by cell line. Colors correspond to strength of representation within each cluster where gray shows limited representation of that cell line within that cluster and red represents that most samples within that cell line fall within that cluster

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