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Fig. 7 | Fluids and Barriers of the CNS

Fig. 7

From: A perfusion bioreactor-based 3D model of the subarachnoid space based on a meningeal tissue construct

Fig. 7

Ingenuity pathway analysis showing regulation of genes that code for components with functions in extracellular matrix remodeling, endo-lysosomal processing and mitochondrial energy metabolism. a For extracellular matrix remodeling up-regulated genes belong to members of the laminin (laminin 1/subunits α (LAMB1) and β2 (LAMA2)), collagen (Type III, XVIII, IV) and integrin family (Integrin α). b For endo-lysosomal processing up-regulated genes belonged to members of the protease (cathepsins A, L and F), galactosidase (β-galactosidase) and mannosidase (α-mannosidase and β-mannosidase) families. c For mitochondrial energy metabolism down-regulated genes found were associated to ETC Complex I, III (ubiquinol binding proteins), IV (cytochrome C oxidase) and V (ATP-snthase) composition and function

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Fluids and Barriers of the CNS

ISSN: 2045-8118