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Fig. 1 | Fluids and Barriers of the CNS

Fig. 1

From: The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells

Fig. 1

Vesicular transport in brain endothelial cells. The endogenous receptor-mediated transcytosis employs vesicular trafficking to transport ligands across the endothelium of the blood–brain barrier. This process involves the complex endo-lysosomal system. The endo-lysosomal system consists of trans-Golgi network, several types of vesicles such as early, recycling and late endosomes, retromer-positive vesicles and lysosomes. Early endosomes are the main sorting stations in the endocytic pathway, receiving receptors and cargos from almost all types of endocytosis. During vesicular sorting, internalized proteins, lipids and receptor–ligand complexes have three main destinations: (i) recycling back to the surface in recycling endosomes, (ii) retrograde trafficking to the trans-Golgi network in retromer-positive vesicles, or (iii) degradation in the lysosomes delivered by late endosomes. To facilitate receptor transport, the cell applies different types of cytosolic adaptor proteins e.g. adaptins or the retromers

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