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Table 8 Parameters and units of drug binding kinetics. The physiological range of values of the parameters is given for rat and human, based on references from the literature

From: The need for mathematical modelling of spatial drug distribution within the brain

Parameter Value (rat) Value (human)
Association rate constant (μmol L−1 s−1) 2.8 × 10−4–2.8 × 102 [238] 2.8 × 10−5–2.8 × 102 [88, 239, 240]
Dissociation rate constant (s−1) 2.8 × 10−7– 2.8 × 10−1[238] 2.8 × 10−7–2.8 × 100[88, 239, 240]
Binding site concentration (μmol L−1) 1 × 10−4– 1 × 10−2 [238] 1 × 10−3–5 × 10−1 [88]