Table 8 Parameters and units of drug binding kinetics. The physiological range of values of the parameters is given for rat and human, based on references from the literature

Association rate constant (μmol L⁻¹ s⁻¹)

2.8 × 10⁻⁴–2.8 × 10² [238]

2.8 × 10⁻⁵–2.8 × 10² [88, 239, 240]

Dissociation rate constant (s⁻¹)

2.8 × 10⁻⁷– 2.8 × 10⁻¹[238]

2.8 × 10⁻⁷–2.8 × 10⁰[88, 239, 240]

Binding site concentration (μmol L⁻¹)

1 × 10⁻⁴– 1 × 10⁻² [238]

1 × 10⁻³–5 × 10⁻¹ [88]