From: The need for mathematical modelling of spatial drug distribution within the brain
Parameter | Value (rat) | Value (human) |
---|---|---|
P, BBB passive permeability (m s−1) | 10–10–10−5 [17] | 6 × 10−8–10−6 [227] |
kBBB, BBB rate constant (s−1) | 1.4 × 10−4–1.4 × 10−2 [132] | |
CLBBB, BBB transfer clearance (10−5 L s−1) | 0.15–8.5 [143] | 113–850 [227] |
Ptrans, BBB transcellular permeability (10−7 m s−1) | 10−3–102 [17] | 0.6–10 [227] |
Dpara, BBB paracellular diffusivity (10−12 m2 s−1) | 467–767 [143] | 550–767 [227] |
WTJ, width tight junction (10−6 m) | ||
Tm, active transporter velocity | 10−5−10−8\(\upmu\)mol s−1 [229] | 22–167 \(\upmu\)mol L−1 s−1 [111] |
Km, concentration to reach half of Tm (103 \(\upmu\)mol L−1) | 10−2−101 [230] | 4.5–5 [111] |
Surface area BBB (m2) | ||
Surface area BCSFB (m2) | 6–9 [17] |