Table 3 Characteristics of models on drug distribution within the brain
From: The need for mathematical modelling of spatial drug distribution within the brain
| Process | Blood flow | BBB transport | Transport within the brain ECF | Cellular exchange | Binding kinetics | Metabolism | ||
|---|---|---|---|---|---|---|---|---|
| Sections: | “Modelling drug transport through the brain capillary system” | “Modelling drug transport across the BBB” | “Modelling drug transport within the brain ECF” | “Modelling intra-extracellular exchange” | “Modelling drug binding kinetics” | “Modelling drug metabolism in the brain” | ||
| Model | Diffusion | Bulk flow | Specific | Non-specific | ||||
| Brain vasculatue | ||||||||
| [125] | + | * | − | − | − | − | − | * |
| [116] | + | + | + | − | − | − | − | − |
| [121] | + | + | + | − | − | − | − | * |
| Brain ECF | ||||||||
| [133] | + | + | + | − | − | − | − | − |
| [154] | + | + | + | − | + | − | − | + |
| [129] | − | * | + | + | + | * | * | * |
| [71, 150, 150, 156, 182, 182, 184] | − | − | + | − | − | − | − | − |
| [33, 164] | − | − | + | + | − | − | − | − |
| [192] | − | − | + | + | − | − | − | * |
| [127] | − | − | + | + | + | * | * | − |
| [107] | − | * | − | + | + | * | − | * |
| [128] | − | * | + | − | − | − | − | − |
| [135, 152] | − | * | + | − | * | − | − | * |
| [153] | − | * | + | − | + | * | * | * |
| [130, 131] | − | * | + | + | − | * | * | * |
| [134] | − | + | + | − | − | − | * | * |
| Compartmental | ||||||||
| [142] | + | + | − | − | + | − | * | − |
| [145] | + | + | − | − | − | − | * | * |
| [136, 137, 139] | − | + | − | − | − | − | − | − |
| [141] | − | + | − | − | + | − | − | − |
| [140, 143] | − | + | − | − | + | − | * | − |
| Hybrid | ||||||||
| [111] | + | + | + | + | + | − | − | + |
| [212] | − | − | − | − | − | − | − | − |
| [106] | − | − | + | + | − | − | − | − |
| [132] | − | * | + | + | * | * | * | * |
| [54] | − | + | − | + | + | − | * | − |
| [126] | − | + | + | + | + | − | * | − |