Table 3 Characteristics of models on drug distribution within the brain
From: The need for mathematical modelling of spatial drug distribution within the brain
Process | Blood flow | BBB transport | Transport within the brain ECF | Cellular exchange | Binding kinetics | Metabolism | ||
|---|---|---|---|---|---|---|---|---|
Sections: | “Modelling drug transport through the brain capillary system” | |||||||
Model | Diffusion | Bulk flow | Specific | Non-specific | ||||
Brain vasculatue | ||||||||
[125] | + | * | − | − | − | − | − | * |
[116] | + | + | + | − | − | − | − | − |
[121] | + | + | + | − | − | − | − | * |
Brain ECF | ||||||||
[133] | + | + | + | − | − | − | − | − |
[154] | + | + | + | − | + | − | − | + |
[129] | − | * | + | + | + | * | * | * |
− | − | + | − | − | − | − | − | |
− | − | + | + | − | − | − | − | |
[192] | − | − | + | + | − | − | − | * |
[127] | − | − | + | + | + | * | * | − |
[107] | − | * | − | + | + | * | − | * |
[128] | − | * | + | − | − | − | − | − |
− | * | + | − | * | − | − | * | |
[153] | − | * | + | − | + | * | * | * |
− | * | + | + | − | * | * | * | |
[134] | − | + | + | − | − | − | * | * |
Compartmental | ||||||||
[142] | + | + | − | − | + | − | * | − |
[145] | + | + | − | − | − | − | * | * |
− | + | − | − | − | − | − | − | |
[141] | − | + | − | − | + | − | − | − |
− | + | − | − | + | − | * | − | |
Hybrid | ||||||||
[111] | + | + | + | + | + | − | − | + |
[212] | − | − | − | − | − | − | − | − |
[106] | − | − | + | + | − | − | − | − |
[132] | − | * | + | + | * | * | * | * |
[54] | − | + | − | + | + | − | * | − |
[126] | − | + | + | + | + | − | * | − |