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Table 9 Parameters and units of drug metabolism in the brain. The physiological range of values of the parameters is given for rat and human, based on references from the literature

From: The need for mathematical modelling of spatial drug distribution within the brain

Parameter Value (rat) Value (human)
Elimination rate constant (103 s−1) 4–19 [129] 1.1 × 10−7–6.8 × 104 [189, 235]
Vmax, maximum reaction flux 2.81 × 10−5 μmol min−1 g−1 [241] 5.76 × 102–1 × 109\(\upmu\)mol L−1 min−1 [111]
Km, affinity constant (103 μmol L−1) 0.319 [241] 0.003–528 [111]