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Table 9 Parameters and units of drug metabolism in the brain. The physiological range of values of the parameters is given for rat and human, based on references from the literature

From: The need for mathematical modelling of spatial drug distribution within the brain

Parameter

Value (rat)

Value (human)

Elimination rate constant (103 s−1)

4–19 [129]

1.1 × 10−7–6.8 × 104 [189, 235]

Vmax, maximum reaction flux

2.81 × 10−5 μmol min−1 g−1 [241]

5.76 × 102–1 × 109\(\upmu\)mol L−1 min−1 [111]

Km, affinity constant (103 μmol L−1)

0.319 [241]

0.003–528 [111]

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Fluids and Barriers of the CNS

ISSN: 2045-8118