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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: The need for mathematical modelling of spatial drug distribution within the brain

Fig. 5

Schematic presentation of the major compartments of the mammalian brain and routes for drug exchange [45]. 1: drug transport through the brain vascular system. 2: drug transport across the brain barriers, including the BBB and the BCSFB. 3: drug transport within the brain fluids (brain ECF and CSF). 4: drug intra-extracellular exchange. 5: drug binding to binding sites that may be intracellular (brown stars), extracellular (yellow stars) or metabolic enzymes (blue stars). Drug binding sites may be present at different sites within the brain. 6: drug metabolism by metabolic enzymes (blue stars). Black arrows: passive transport. White arrows: active transport. Blue arrows: metabolic reactions. The image by [45] is licensed under CC BY 2.0 and modified for the purpose of this review

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