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Fig. 15 | Fluids and Barriers of the CNS

Fig. 15

From: The need for mathematical modelling of spatial drug distribution within the brain

Fig. 15

Mathematical representations of drug distribution within the brain. Left: “schematic presentation of the major compartments of the mammalian brain and routes for drug exchange” [45]. The image shows the processes of drug distribution within the brain covered by mathematical models. Processes include cerebral blood flow and plasma binding (see “Modelling drug transport through the brain capillary system”), BBB transport (see “Modelling drug transport across the BBB”), transport within the brain ECF (see “Modelling drug transport within the brain ECF)” intra-extracellular exchange (see “Modelling intra-extracellular exchange”), binding (see “Modelling drug binding kinetics”) and metabolism (see “Modelling drug metabolism in the brain”). The image by [45] is licensed under CC BY 2.0 and modified for the purpose of this review. Right: simplified representation of drug distribution within the brain by a compartmental model. See Table 2 for references. Drug exchange between compartments but not within compartments is described (see “Modelling drug exchange between compartments”)

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