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Fig. 11 | Fluids and Barriers of the CNS

Fig. 11

From: The need for mathematical modelling of spatial drug distribution within the brain

Fig. 11

Adapted with permission from [54]

Schematic representation of the model by Trapa [54] discussed in the text. In the model, used to extract active permeability from in vitro transwell permeability experiments, passive (Ppas) and active (Pact) permeability, paracellular (Ppara) transport, and the effects of unstirred water layers (UWLs) are considered on both the apical and basolateral sides of the membrane.

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