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Table 1 Solute and pH levels in the venous blood and CSF samples simultaneously extracted from 16 subjects

From: The human central nervous system discharges carbon dioxide and lactic acid into the cerebrospinal fluid

 

Venous blood

CSF

p-value

pH

7.40 ± 0.03

7.33 ± 0.04

< 0.0001

pO2 [mmHg]

53.7 ± 12.1

77.0 ± 8.7

< 0.0001

pCO2 [mmHg]

41.3 ± 5.1

48.5 ± 3.9

< 0.0001

SBE [mmol/L]

1.03 ± 2.31

− 0.21 ± 1.81

0.0266

HCO3− [mmol/L]

25.3 ± 2.4

24.9 ± 1.5

0.429

Na+ [mmol/L]

139.7 ± 2.0

140.1 ± 1.6

0.343

K+ [mmol/L]

3.78 ± 0.38

2.73 ± 0.10

< 0.0001

Cl− [mmol/L]

103.7 ± 3.1

118.1 ± 2.7

< 0.0001

AG (K+) [mmol/L]

14.0 ± 1.5

− 0.1 ± 2.7

< 0.0001

Lac [mmol/L]

1.01 ± 0.35

1.46 ± 0.20

0.0004

t-Bil [mg/dL]

0.92 ± 0.62

0.02 ± 0.04

< 0.0001

  1. The mean pO2 was significantly higher in the CSF than in venous blood samples, as were the mean pCO2 and lactic acid levels, suggesting that these metabolic wastes were discharged from the central nervous system into the CSF via some drainage system. All p-values are the result of a paired t-test as a parametric test or a Wilcoxon signed-rank test as a non-parametric test
  2. AG, anion gap; Cl−, chloride ion; CSF, cerebrospinal fluid; HCO3−, bicarbonate; K+, potassium ion; Na+, sodium ion; pCO2, carbon dioxide partial pressure; Lac, lactic acid; pO2, oxygen partial pressure; SBE, standard base excess; t-Bil, total bilirubin
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Fluids and Barriers of the CNS

ISSN: 2045-8118