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Table 5 Summary of boundary condition sensitivity analysis

From: Analysis of convective and diffusive transport in the brain interstitium

Description

\(C_{max,mean}\) (mM)

Range

Experimental

1.1

0.70

Boundary conditions

 Tight perivascular walls (\(D_{wall} = 5\% D_{ECS}\))

1.2

0.66

 Loose perivascular walls (\(D_{wall} = D_{ECS}\))

0.86

1.17

 Loose perivascular walls, no flux condition on arterioles (\(D_{wall} = D_{ECS}\))

1.2

0.75

  1. For boundary condition sensitivity, base case is diffusion and convection (\({\text{v}}\) = 50 μm min−1) with perivascular exchange using vessel separation = 250 μm
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Fluids and Barriers of the CNS

ISSN: 2045-8118