From: Analysis of convective and diffusive transport in the brain interstitium
Description | \(C_{max,mean}\) (mM) | Range |
---|---|---|
Experimental | 1.1 | 0.70 |
Simulation base case: diffusion only in homogeneous tissue (no perivascular exchange) | 1.2 | 0.0 |
Estimates of range contribution from experimental variability | ||
 Inter-animal and intra-animal tissue variation: void volume (± 0.005) | 1.2 | 0.12 |
 Inter-animal and intra-animal tissue variation: tortuosity (± 0.05) | 1.2 | 0.09 |
 Error in probe separation distance (± 2 μm) | 1.2 | 0.02 |
 Other factors (e.g., tissue damage) | 1.2 | Unknown |
 Diffusion only plus est. experimental variability | 1.2 | 0.23 |
Additional transport mechanisms (convection, perivascular exchange) | ||
 Diffusion with perivascular exchange (λ = 1.85) Varying vessel separation (distance in parentheses) | 1.25 (225 μm) 1.28 (250 μm) 1.31 (275 μm) | 0.44 (225 μm) 0.47 (250 μm) 0.42 (275 μm) |
 Diffusion and convection (\(v\) = 50 μm min−1) in homogeneous tissue (no perivascular exchange) | 1.2 | 0.24 |
 Diffusion and convection with perivascular exchange (λ = 1.85) Varying bulk-flow velocity (in parentheses) | 1.2 (10 μm min−1) 1.2 (50 μm min−1) 1.2 (100 μm min−1) 1.0 (250 μm min−1) | 0.5 (10 μm min−1) 0.7 (50 μm min−1) 0.9 (100 μm min−1) 1.7 (250 μm min−1) |