Analysis of convective and diffusive transport in the brain interstitium

Table 3 Simulation results for bulk-flow superficial-velocity in the brain interstitium

Hydraulic conductivity (cm² mmHg⁻¹ s⁻¹)	Average bulk-flow superficial-velocity (μm min⁻¹)
Hydraulic conductivity (cm² mmHg⁻¹ s⁻¹)	For P_avg = 0.2 mmHg	For P_max = 1 mmHg P_avg = 0.8 mmHg	For P_max = 3 mmHg P_avg = 2.4 mmHg	For P_max = 10 mmHg P_avg = 8 mmHg
2 × 10⁻⁶ [38, 45]^a	5	25	75	250
2 × 10⁻⁷ [46]	0.5	2.5	7.5	25
2 × 10⁻⁸ [35]	0.05	0.25	0.75	2.5

Volume-averaged (over full domain), time-averaged velocity is reported for each condition. A range of hydraulic conductivity values from the literature are reported and used in the simulation. A range of periarteriolar wall pressures are used, and further described in the text. Wall pressure is an oscillatory function in the model; maximum and mean pressure are reported in the table
^aReports value of 1.2 × 10⁻⁶ cm² mmHg⁻¹ s⁻¹, for parenchyma only based on simulation

ISSN: 2045-8118