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Table 3 Simulation results for bulk-flow superficial-velocity in the brain interstitium

From: Analysis of convective and diffusive transport in the brain interstitium

Hydraulic conductivity (cm2 mmHg−1 s−1) Average bulk-flow superficial-velocity (μm min−1)
For
Pavg = 0.2 mmHg
For
Pmax = 1 mmHg
Pavg = 0.8 mmHg
For
Pmax = 3 mmHg
Pavg = 2.4 mmHg
For
Pmax = 10 mmHg
Pavg = 8 mmHg
2 × 10−6 [38, 45]a 5 25 75 250
2 × 10−7 [46] 0.5 2.5 7.5 25
2 × 10−8 [35] 0.05 0.25 0.75 2.5
  1. Volume-averaged (over full domain), time-averaged velocity is reported for each condition. A range of hydraulic conductivity values from the literature are reported and used in the simulation. A range of periarteriolar wall pressures are used, and further described in the text. Wall pressure is an oscillatory function in the model; maximum and mean pressure are reported in the table
  2. aReports value of 1.2 × 10−6 cm2 mmHg−1 s−1, for parenchyma only based on simulation