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Table 1 Summary of ECS structural parameters determined by TMA-RTI experiments on neocortex of healthy, anesthetized adult rat and mice (layer indicated in table)

From: Analysis of convective and diffusive transport in the brain interstitium

Reference

Preparation

Void volume

Tortuosity

Mice

 Xie [24]

In vivo

0.227 ± 0.003

1.55 ± 0.05

 Kress [25]

In vivo

0.224 ± 0.080

1.50 ± 0.11

Rat: cortex layers V and VI

 Lehmenkuhler [26]

In vivo

0.23 ± 0.005

1.59 ± 0.018

 Vorisek [27]

In vivo

0.23 ± 0.02

1.55 ± 0.02

 Mazel [28]

In vivo

0.22 ± 0.01

1.60 ± 0.02

 Kume-Kick [29]

Brain slice

0.24

1.72

Rat: cortex layers II and III

 Lehmenkuhler [26]

In vivo

0.20 ± 0.003

1.57 ± 0.03

 Cserr [30]

In vivo

0.18 ± 0.03

1.57 ± 0.05

 Mazel [28]

In vivo

0.22 ± 0.01

1.61 ± 0.01

 Perez-Pinzon [31]

Brain slice

0.18 ± 0.008

1.62 ± 0.039

  1. Uptake constant omitted from table because it has not been observed to vary much over in vivo rat brain experiments, 0.003–0.006 s−1 [20]