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Table 1 Summary of ECS structural parameters determined by TMA-RTI experiments on neocortex of healthy, anesthetized adult rat and mice (layer indicated in table)

From: Analysis of convective and diffusive transport in the brain interstitium

Reference Preparation Void volume Tortuosity
Mice
 Xie [24] In vivo 0.227 ± 0.003 1.55 ± 0.05
 Kress [25] In vivo 0.224 ± 0.080 1.50 ± 0.11
Rat: cortex layers V and VI
 Lehmenkuhler [26] In vivo 0.23 ± 0.005 1.59 ± 0.018
 Vorisek [27] In vivo 0.23 ± 0.02 1.55 ± 0.02
 Mazel [28] In vivo 0.22 ± 0.01 1.60 ± 0.02
 Kume-Kick [29] Brain slice 0.24 1.72
Rat: cortex layers II and III
 Lehmenkuhler [26] In vivo 0.20 ± 0.003 1.57 ± 0.03
 Cserr [30] In vivo 0.18 ± 0.03 1.57 ± 0.05
 Mazel [28] In vivo 0.22 ± 0.01 1.61 ± 0.01
 Perez-Pinzon [31] Brain slice 0.18 ± 0.008 1.62 ± 0.039
  1. Uptake constant omitted from table because it has not been observed to vary much over in vivo rat brain experiments, 0.003–0.006 s−1 [20]