Fig. 8
From: Analysis of convective and diffusive transport in the brain interstitium
Aβ clearance from interstitial injection, experimental data compared with simulations. Experimental data from Iliff for Aqp4 KO and WT mice [4]. Simulation results at various bulk-flow rates and for diffusion only. Details of simulation described in “Methods”. Periarteriolar wall and perivenular wall diffusivities are 2.5% and 5% of interstitial diffusivity respectively, to fit experimental data for Aqp4 null mice (which are hypothesized to have no bulk flow in the interstitium). Based on conservative assumptions, simulations for a bulk-flow velocity of 7 μm min−1 fit the experimental data for WT mice