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Table 1 Effects of hydrocephalus on pituitary function

From: Comorbidity of diabetes mellitus in idiopathic normal pressure hydrocephalus: a systematic literature review

Year

Author

Type of hydrocephalus

Pituitary function findings

Type of study

2012

Moin et al. [16]

iNPH

Decreased IGF-1

Experimental study

2011

Pinto et al. [17]

Chronic hydrocephalus

Decreased growth hormone

Single case study

1997

Löppönen et al. [18]

Shunted hydrocephalus

Decreased growth hormone***

Controlled cross sectional study

1998

Löppönen et al. [19]

Shunted hydrocephalus

Decrease in growth hormone and IGF-1 post shunting

Case study

1977

Hier et al. [20]

Chronic hydrocephalus

Decreased growth hormone

Multiple case study

2016

Vieira et al. [21]

Post hemorrhagic acute phase hydrocephalus

Patients with hydrocephalus had increased pituitary dysfunction when compared to non-hydrocephalus patients***

Cohort study

1978

Barber et al. [22]

iNPH

Decreased growth hormone

Single case report

1979

Barber et al. [23]

iNPH

Hypopituitarism

Multiple case report

1997

Hochhaus et al. [24]

Hydrocephalus

Decreased IGF-1***

Cross sectional study

2015

Khajeh et al. [25]

Post hemorrhagic hydrocephalus

Pituitary dysfunction and growth hormone deficiency

Case study

  1. Studies examining the effects of multiple types of hydrocephalus on pituitary function specifically related to growth hormone/IGF-1. Pituitary function findings indicated with (***) indicate a statistically significant result compared to age and cohort matched controls