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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Claudin-5: gatekeeper of neurological function

Fig. 2

(Adapted from [44])

Structure of claudin-5. Claudin-5 consists of 4 transmembrane domains (TM), a short NH2 terminus, two extracellular loops (ECL), a short intracellular loop and a longer COOH terminus. ECL1 contains a disulphide bond and ion binding site as well as a highly conserved signature motif. The long COOH terminus contains the PDZ binding motif for interactions with scaffolding proteins including ZO-1, -2 and -3. Additionally, the COOH terminus contains trafficking and phosphorylation residues

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