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Fig. 1 | Fluids and Barriers of the CNS

Fig. 1

From: Claudin-5: gatekeeper of neurological function

Fig. 1

Inter-endothelial connections. Located closest to the apical membrane are the tight junction proteins consisting of claudin-1, -3, -5, -12; occludin; and lipolysis-stimulated protein (LSR) which limit paracellular diffusion of ions and solutes across the tightly packed monolayer of endothelial cells. Zonula occludens (ZO)-1, -2 and -3 binds to PDZ motifs on intracellular domains of claudins and occludin and bind to the actin cytoskeleton, providing structural integrity to the tight junction. Other junctional complexes contribute to tight junction properties including junctional adhesion molecule (JAM)-A, -B and -C and endothelial cell adhesion molecules (ESAM). Gap junctions such as connexin-37 and -40 form hemichannels between opposing endothelial cell membranes, contributing to intercellular communication. Located closest to the basolateral membrane are the adherens junction proteins including vascular endothelial (VE)-cadherin and platelet endothelial cell adhesion molecule-1 (PECAM-1)

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