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Fig. 4 | Fluids and Barriers of the CNS

Fig. 4

From: Disruption of the hippocampal and hypothalamic blood–brain barrier in a diet-induced obese model of type II diabetes: prevention and treatment by the mitochondrial carbonic anhydrase inhibitor, topiramate

Fig. 4

Measurement of blood–brain barrier permeability changes in diet-induced obesity. These histograms are representative of data highlighted in Tables 1 and 2. 14C-labeled sucrose (342 Da; Table 2) was used to measure BBB permeability changes in the whole brain (a prevention; g efficacy), hypothalamus (b prevention; h efficacy), and hippocampus (c prevention; i efficacy). 99mTc-labeled albumin (65 kDa; Table 1) was used to measure BBB permeability changes in the whole brain (d prevention; j efficacy), hypothalamus (e prevention; k efficacy), and hippocampus (f prevention; l efficacy). Values are expressed as mean ± SD. Significance was determined by a one-way analysis of variance followed by Newman–Keuls post-test for HF vs. LF, LF vs. LF TPM, and HF vs. HF TPM. *p < 0.05; **p < 0.01; #p < 0.001

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