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Table 4 Unchanged genes with possible tendency of upregulation in AD CP

From: Choroid plexus genes for CSF production and brain homeostasis are altered in Alzheimer’s disease

Gene symbol

Gene name

p-value

t-value (control relative to AD)

Log2 fold change

SLC family

 SLC39A4

Solute carrier family 39 member 4; ZIP4 metal ion transporter

0.806

− 0.25019879

− 0.03455714

Carbonic anhydrase family

 CA7

Carbonic anhydrase 7

0.310

− 1.05004961

− 0.16493333

 CA5B

Carbonic anhydrase 5B

0.149

− 1.5231615

− 0.23130952

 CA11

Carbonic anhydrase 11

0.445

− 0.78401027

− 0.1202119

Other genes

 PSEN1

Presenilin 1

0.0687

− 1.96233878

− 0.23186667

 PSEN2

Presenilin 2

0.182

− 1.39857889,

− 0.1595881

 AQP1

Aquaporin 1

0.367

− 0.93107284

− 0.11615238

  1. Negative t values are for comparisons displaying gene changes that are increased in AD relative to control (i.e. decreased in control relative to AD). The same is true for negative log2FC values
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Fluids and Barriers of the CNS

ISSN: 2045-8118