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Table 3 Unchanged genes with possible tendency of downregulation in AD CP

From: Choroid plexus genes for CSF production and brain homeostasis are altered in Alzheimer’s disease

Gene symbol

Gene name

p-value

t-value (control relative to AD)

Log2 fold change

SLC family

 SLC12A4

Solute carrier family 12 member 4: KCC1 K–Cl cotransporter

0.0947

1.78492648

0.23569524

 SLC4A2

Solute carrier family 4 member 2: Cl–HCO3 exchanger

0.130

1.60190388

0.21841905

 SLC38A3

Solute carrier family 38 member 3; system N amino acid transporter

0.223

1.27232445

0.2807

Na–K ATPase family

 ATP1B2

Na–K ATPase transporting subunit beta 2

0.0533

2.09928405

0.39634524

 ATP1A4

Na–K ATPase transporting subunit alpha 4

0.684

0.41463513

0.06897143

Carbonic anhydrase family

 CA8

Carbonic anhydrase 8

0.138

1.56854024

0.50962619

 CA14

Carbonic anhydrase 14

0.172

1.4334038

0.29066667

Tight junction claudins and occludin

 CLDN1

Claudin-1

0.188

1.37904737

0.35589048

 CLDN2

Claudin-2

0.161

1.47424712

0.43342857

 CLDN3

Claudin-3

0.0942

1.78793258

0.41007381

 CLDN19

Claudin-19

0.375

0.91449198

0.32223095

 OCLN

Occludin

0.799

0.25905032

0.03019762

Others

 AQP4

Aquaporin 4

0.621

0.50457389

0.18047619

  1. Positive t values for comparisons represent gene changes decreased in AD relative to control (i.e. increased in control relative to AD). The same is true for positive log2FC values
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Fluids and Barriers of the CNS

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