Choroid plexus genes for CSF production and brain homeostasis are altered in Alzheimer’s disease

Table 2 Genes upregulated in AD CP

Gene symbol	Gene name	p-value	t-value (control relative to AD)	Log2 fold change
SLC family
SLC25A37	Solute carrier family 25 member 37: mitochondrial iron transporter	0.000128	− 5.12740967	− 0.64122381
SLC25A28	Solute carrier family 25 member 28; mitochondrial iron transporter	0.0000927	− 5.29698098	− 0.64098333
SLCO4A1	Solute carrier organic anion transporter family member 4A1; organic anion transporter	0.000103	− 5.24167279	− 1.85499048
SLC12A7	Solute carrier family 12 member 7; KCC4 K–Cl cotransporter	0.000741	− 4.23121588	− 0.67435
SLC12A6	Solute carrier family 12 member 6; KCC3 K–Cl cotransporter	0.0262	− 2.46864419	− 0.52261429
Interleukin-1-receptor family
IL1R1	Interleukin-1 receptor	0.0185	− 2.64459755	− 0.62269524
IL1RL1	Interleukin 1 receptor-like 1	0.0000113	− 6.45879688	− 3.43624762
Carbonic anhydrase family
CA13	Carbonic anhydrase 13	0.0152	− 2.74368279	− 0.51382619
Na–K ATPase family
ATP1A1	Na–K ATPase transporting subunit alpha 1	0.0198	− 2.61012511	− 0.45077857
Amyloid proteins
ABPA3	Amyloid beta precursor protein (APP) binding family A member 3	0.00154	− 3.86960931	− 0.51001667
APBB1IP	APP binding family B member 1 interacting protein	0.0116	− 2.87838249	− 0.53602143

Negative t values are for comparisons displaying gene changes that are increased in AD relative to control (i.e. decreased in control relative to AD). The same is true for negative log2FC values

ISSN: 2045-8118