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Table 1 Genes downregulated in AD CP

From: Choroid plexus genes for CSF production and brain homeostasis are altered in Alzheimer’s disease

Gene symbol Gene name p-value t-value (control relative to AD) Log2 fold change
SLC family
 SLC26A2 Solute carrier family 26 member 2; sulfate transporter 0.0000313 5.88360095 1.43830952
 SLC5A5 Solute carrier family 5 member 5; sodium/iodine cotransporter 0.0000375 5.78520397 0.75760238
 SLC4A10 Solute carrier family 4 member 10: Na-dependent Cl–HCO3 exchanger 0.0275 2.44489236 0.39339524
 SLC4A5 Solute carrier family 4 member 5: Na–HCO3 exchanger 0.00366 3.44425553 1.1215619
 SLC12A1 Solute carrier family 12 member 1: NKCC2 Na–K–Cl cotransporter 0.0353 2.31563648 1.05009524
 SLC12A2 Solute carrier family 12 member 2: NKCC1 Na–K–Cl cotransporter 0.00517 3.27527462 0.38004286
Na–K ATPase family
 ATP1A2 Na–K ATPase transporting subunit alpha 2 0.0387 2.26741686 0.50910238
 ATP1B1 Na–K ATPase transporting subunit beta 1 0.0429 2.21376353 0.29179286
Carbonic anhydrase family
 CA4 Carbonic anhydrase 4 0.000139 5.08319761 0.63055238
 CA2 Carbonic anhydrase 2 0.0222 2.55323972 0.30442619
 CA3 Carbonic anhydrase 3 0.0391 2.26309122 0.58876429
ATP synthase family
 ATP5L ATP synthase, H+ transporting, mitochondrial Fo complex subunit G 0.000419 4.51769377 0.44282857
 ATP23 ATP23 metallopeptidase and ATP synthase assembly factor homolog 0.000780 4.20573756 0.62625
 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 0.00154 3.86838238 0.65084286
 ATPAF1 ATP synthase mitochondrial F1 complex assembly factor 1 0.00269 3.59573018 0.56412619
 ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 0.0107 2.91564259 0.45252381
Tight junction claudins
 CLDN18 Claudin-18 0.0105 2.92789759 0.46640476
 CLDN11 Claudin-11 0.0190 2.63115902 0.64749762
 CLDN5 Claudin-5 0.0399 2.25235984 0.70879524
Others
 APP Amyloid beta precursor protein 0.0144 2.77007349 0.41097857
  1. Positive t values for comparisons represent gene changes decreased in AD relative to control (i.e. increased in control relative to AD). The same is true for positive log2FC values