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Table 1 Genes downregulated in AD CP

From: Choroid plexus genes for CSF production and brain homeostasis are altered in Alzheimer’s disease

Gene symbol

Gene name

p-value

t-value (control relative to AD)

Log2 fold change

SLC family

 SLC26A2

Solute carrier family 26 member 2; sulfate transporter

0.0000313

5.88360095

1.43830952

 SLC5A5

Solute carrier family 5 member 5; sodium/iodine cotransporter

0.0000375

5.78520397

0.75760238

 SLC4A10

Solute carrier family 4 member 10: Na-dependent Cl–HCO3 exchanger

0.0275

2.44489236

0.39339524

 SLC4A5

Solute carrier family 4 member 5: Na–HCO3 exchanger

0.00366

3.44425553

1.1215619

 SLC12A1

Solute carrier family 12 member 1: NKCC2 Na–K–Cl cotransporter

0.0353

2.31563648

1.05009524

 SLC12A2

Solute carrier family 12 member 2: NKCC1 Na–K–Cl cotransporter

0.00517

3.27527462

0.38004286

Na–K ATPase family

 ATP1A2

Na–K ATPase transporting subunit alpha 2

0.0387

2.26741686

0.50910238

 ATP1B1

Na–K ATPase transporting subunit beta 1

0.0429

2.21376353

0.29179286

Carbonic anhydrase family

 CA4

Carbonic anhydrase 4

0.000139

5.08319761

0.63055238

 CA2

Carbonic anhydrase 2

0.0222

2.55323972

0.30442619

 CA3

Carbonic anhydrase 3

0.0391

2.26309122

0.58876429

ATP synthase family

 ATP5L

ATP synthase, H+ transporting, mitochondrial Fo complex subunit G

0.000419

4.51769377

0.44282857

 ATP23

ATP23 metallopeptidase and ATP synthase assembly factor homolog

0.000780

4.20573756

0.62625

 ATP5G3

ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9)

0.00154

3.86838238

0.65084286

 ATPAF1

ATP synthase mitochondrial F1 complex assembly factor 1

0.00269

3.59573018

0.56412619

 ATP5B

ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide

0.0107

2.91564259

0.45252381

Tight junction claudins

 CLDN18

Claudin-18

0.0105

2.92789759

0.46640476

 CLDN11

Claudin-11

0.0190

2.63115902

0.64749762

 CLDN5

Claudin-5

0.0399

2.25235984

0.70879524

Others

 APP

Amyloid beta precursor protein

0.0144

2.77007349

0.41097857

  1. Positive t values for comparisons represent gene changes decreased in AD relative to control (i.e. increased in control relative to AD). The same is true for positive log2FC values