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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Patient-specific cranio-spinal compliance distribution using lumped-parameter model: its relation with ICP over a wide age range

Fig. 2

Example of determination of cranial contribution to cranio-spinal compliance from sample input and output waveforms. a Flow compensated magnitude image showing bright signal from blood vessels. b High-velocity encoding images used for measurements of arterial inflow and venous outflow. c Low-velocity encoding images used for measurements of CSF flow. d Phase contrast MRI derived cardiac cycle of QAV (red) and QCSF (green) in an 21-year-old healthy female subject is plotted. QAV is used as input to the model, which predicts the inverted QCSF (black) waveform. e Histogram corresponding to model-derived spinal contribution to cranio-spinal compliance, CS/(CC + CS), is plotted for all the model parameters that give E > 0.7. The final spinal contribution to CSC is chosen from the mode of the histogram (60%)

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