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Fig. 13 | Fluids and Barriers of the CNS

Fig. 13

From: Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier

Fig. 13

Interpretation of net flux of a single solute, obligatory exchange, and trans-stimulation in terms of a simple carrier model. In each case the concentration of the first solute (filled black circle) is higher on the cis side (left) than on the trans side (right). a Net flux of solute from cis to trans is supported by return of the free carrier. b If return of the carrier is only possible with a solute bound, there is obligatory exchange, either self-exchange or counter-transport of another solute (circle). c Trans-stimulation is a combination of these two effects. Flux of the first solute from cis to trans can be increased if there is more solute (either sort) on the trans side (here the right) provided that increases the rate of return of the carrier—i.e. it increases the rate of conformation changes of the carrier from trans-facing to cis-facing

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