Fig. 12

Structure of the human glucose transporter GLUT1. The structure of full-length human GLUT1 containing two point mutations (N45T, E329Q) was determined in an inward-open conformation. The side and cytoplasmic views are shown. The corresponding transmembrane segments in the four 3-helix repeats are coloured the same. The extracellular and intracellular helices are coloured blue and orange, respectively. A slab of cut- open view of the surface electrostatic potential, which was calculated with PyMol50, is shown on the right to facilitate visualization of the inward-facing cavity. IC indicates intracellular helix. Reprinted by permission from Springer Nature from Nature 510, 121–126, Crystal structure of the human glucose transporter GLUT1 by Deng et al. [321]