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Table 2 Ionic composition and concentrations of various other solutes in the CSF of WKY and SHR rats

From: Blood–brain and blood–cerebrospinal fluid barrier permeability in spontaneously hypertensive rats

 

WKY

SHR

Na+

156.3 ± 0.31 (n = 4)

157.5 ± 0.25 (n = 4)*

K+

2.76 ± 0.02 (n = 4)

2.77 ± 0.01 (n = 4)

Cl−

130.1 ± 0.31 (n = 4)

131.3 ± 0.54 (n = 4)

Ca2+

1.29 ± 0.01 (n = 3)

1.27 ± 0.01 (n = 4)

Glucose

8.11 ± 0.30 (n = 4)

5.26 ± 0.20 (n = 4)***

IgG

< 0.30 (n = 3)

< 0.30 (n = 8)

Total protein

0.15 ± 0.002 (n = 5)

0.11 ± 0.01 (n = 7)*

  1. Glucose levels were significantly lower in SHR as compared to WKY, but were remarkably high in both groups
  2. WKY Wistar Kyoto rat, SHR spontaneously hypertensive rat; IgG, Immunoglobulin G
  3. Na+ concentrations were significantly higher in SHR, whereas none of the other ion concentrations were different. Total protein concentrations were significantly lower in SHR. Na+, K+, Cl−, Ca2+, and glucose levels are in mmol/L, whereas IgG and total protein are in g/L. Values are mean ± SEM. * p ≤ 0.05, *** p ≤ 0.001 vs. WKY (unpaired Student’s t-test)
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Fluids and Barriers of the CNS

ISSN: 2045-8118