Fig. 1
From: Blood–brain and blood–cerebrospinal fluid barrier permeability in spontaneously hypertensive rats
Changes in ICP during collection of CSF from the cisterna magna, baseline ICP, and CSF production rate in WKY and SHR. a In this animal, the mean baseline ICP of 4.0 mmHg was measured during the first 5 min of the experiment. Subsequently, a CSF sample was collected over a short period of about 1 min until an ICP of 0.5 mmHg was reached. The animal was then allowed to refill the withdrawn CSF volume for another 30 min, from which the CSF production rate could be calculated. The inset shows a zoom in on the ICP recording, with approximately 1 breath and 4 to 5 heart beats per second. b Mean baseline ICP was not different between WKY (n = 10) and SHR (n = 10). c Also, CSF production rates did not differ between WKY (n = 6) and SHR (n = 10). Values are mean ± SEM (unpaired Student’s t-test)