Table 1 Overview of experimental animal groups
From: Cerebral influx of Na+ and Cl− as the osmotherapy-mediated rebound response in rats
Experiment | Label | Osmotic agent | Treatment | Delivery route | # rats |
|---|---|---|---|---|---|
Brain water and ion quantification | Control | – | Vehicle | i.v. | 9 |
– | Inhibitors | i.v. | 7 | ||
– | Vehicle | i.c.v. | 6 | ||
– | Inhibitors | i.c.v. | 6 | ||
Osmotherapy | NaCl (i.p.) | Vehicle | i.v. | 9 | |
NaCl (i.p.) | Inhibitors | i.v. | 8 | ||
NaCl (i.p.) | 3× vehicle | i.v. | 4 | ||
NaCl (i.p.) | 3× inhibitors | i.v. | 4 | ||
NaCl (i.p.) | Vehicle | i.c.v. | 6 | ||
NaCl (i.p.) | Inhibitors | i.c.v. | 6 | ||
Mannitol (i.p.) | – | – | 6 | ||
Naïve | – | – | – | 3 | |
Brain barrier permeability | Control | – | NaFl | i.v. | 3 |
Osmotherapy | NaCl (i.p.) | NaFl | i.v. | 3 | |
Naïve | – | – | – | 3 | |
Monitoring of ICP | – | Evans blue | i.c.v. | 3 | |
Blood pressure measurement | – | Vehicle | i.v. | 3 | |
– | Inhibitors | i.v. | 3 |