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Fig. 4 | Fluids and Barriers of the CNS

Fig. 4

From: Cerebral influx of Na+ and Cl as the osmotherapy-mediated rebound response in rats

Fig. 4

Inhibition of choroidal ion-transporting mechanisms does not affect brain water loss or electrolyte gain. a Representative image of brain hemispheres following Evans blue injection into the right lateral ventricle (stained lateral ventricles highlighted in dashed ovals), n = 3. b A representative epidural ICP trace with jugular vein compression included as a positive control. The inset shows mean ∆ICP ± SEM (mmHg) during intraventricular injection, n = 3. c Brain water content (in ml/g dry weight) of rats treated with intraventricular injections of vehicle or inhibitors prior to i.p. administration of isosmolar NaCl (control; vehicle: 3.75 ± 0.01 vs. inhibitors: 3.74 ± 0.02) or hyperosmolar NaCl (osmotherapy; vehicle: 3.42 ± 0.01 vs. inhibitors: 3.44 ± 0.03), n = 6 of each. d The brain Na+ content (in mmol/kg dry weight) in control rats treated with vehicle (200 ± 1) or inhibitors (197 ± 3) and in osmotherapy-treated rats exposed to vehicle (224 ± 3) or inhibitors (224 ± 3), n = 6 of each. e The brain Cl content (in mmol/kg dry weight) in control rats treated with vehicle (162 ± 3) or inhibitors (166 ± 3) and in osmotherapy-treated rats exposed to vehicle (198 ± 4) or inhibitors (203 ± 2), n = 6 of each. Statistical significant differences were determined by a two-way ANOVA with Tukey’s multiple comparisons post hoc test. ns not significant

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