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Fig. 1 | Fluids and Barriers of the CNS

Fig. 1

From: Sex-specific differences in organic anion transporting polypeptide 1a4 (Oatp1a4) functional expression at the blood–brain barrier in Sprague–Dawley rats

Fig. 1

Expression of endothelial cell, astrocyte, and neuronal marker proteins in brain microvessels isolated from male and female Sprague–Dawley rats. Western blot analysis shows the presence of a single band corresponding to the endothelial marker platelet endothelial cell adhesion molecule-1 (PECAM-1; also known as CD31) (130 kDa) in male (M1–6) and female (F1–6) experimental animals. While single bands for the astrocyte marker glial fibrillary acidic protein (GFAP) (50 kDa) and the neuronal marker synaptophysin (37 kDa) in samples prepared from male and female animals, their expression was considerably lower as compared to PECAM. These observations emphasize the high purity of the microvessel preparations utilized in all subsequent experiments

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