Fluids and Barriers of the CNS

Table 1 PLVAP expression in non-barrier endothelium detected with PAL-E (human tissue) and MECA-32 (mouse tissue)

From: The role of plasmalemma vesicle-associated protein in pathological breakdown of blood–brain and blood–retinal barriers: potential novel therapeutic target for cerebral edema and diabetic macular edema

	PAL-E	MECA-32	References
*Vascular system*
Arteries
Large elastic	–	ND	[22]
Medium-sized and small	± or −	ND	[22]
Arterioles	± or −	+	[22, 30]
Capillaries	+	±	[22, 30]
Venules	+	+	[22, 30]
Veins
Medium-sized and small	+	ND	[22]
Large elastic	−	+	[22, 30]
*Lymphatic system*
Lymphatic vessels	−	−	[22, 118]
Lymph node
Subcapsular sinus	ND	+	[60]
Sinus histiocytes	−	ND	[22]
*Kidney*
Adult kidney
Glomeruli	−	±	[30, 119]
Endothelium^a	+	+	[30, 119]
Fetal kidney
Glomeruli	+	ND	[30, 119]
Endothelium^a	+	ND	[30, 119]
*Liver*
Adult liver
Sinusoids	−	ND	[22]
Periportal area	+	ND	[22]
Fetal liver
Sinusoids	+	+	[58, 98]
*Muscle*
Cardiac muscle	±	+	[30, 33]
Skeletal muscle	±	+	[30, 33]
Bladder	+	ND	[33]
Gut	+	ND	[33]
*Other tissues*
Lung	ND	+	[30, 55]
Pancreas	ND	+	[30, 58]
Spleen
Sinusoids	+	+	[22, 30]
Skin	+	+^b	[23, 55]
Thymus	+	+	[30, 45]
Intestine	ND	+	[30, 55, 58]

Grading: −, no staining; ±, variable staining; +, positive staining; ND, not determined
^aNon-glomerular blood vessel endothelium
^bOnly reported in embryonic mouse tissue (E16.5)

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ISSN: 2045-8118

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