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Fig. 9 | Fluids and Barriers of the CNS

Fig. 9

From: Accurate, strong, and stable reporting of choroid plexus epithelial cells in transgenic mice using a human transthyretin BAC

Fig. 9

Real-time rt-qPCR revealed long-term expression of TTR and tdTomato mRNA. a Values across all animals from the 3154 founder line indicated a greater abundance of tdTomato transcript in the ChP than in the liver, and the difference was similar to that detected for transthyretin. b When expressed as a function of age, tdTomato transcripts in the ChP declined slightly but significantly in the 3154 founder line, whereas tdTomato transcripts in the liver increased significantly. In contrast, transthyretin transcripts remained steady with age in both ChP and liver. The small decline in tdTomato expression across age in the 3154 line was recapitulated in both the 3147 (c) and 3161 (d) founder lines, but the increase in tdTomato transcript in the liver was not observed for the 3147 and 3161 lines. Levels of transthyretin transcripts did not change significantly with age in either the ChP or liver in either the 3147 or 3161 founder line. TdTomato and transthyretin in the 3154 founder line did not differ between the sexes (e) or across generations (f). Heights of bars indicate mean values, error bars denote standard deviations, and trendlines are the results of linear regression

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