Fig. 11

Luciferase activity is high in the ChP of transgenic mice. Luciferase activity measured in lysates of various tissues in two different founder lines showed a rank order largely consistent with the intensity of tdTomato native fluorescence, with no detection of luciferase in tissues that do not express TTR (a). The specific activity of luciferase in both the ChP and the eye declined rapidly from high perinatal values to steadily detectable levels that persisted well into adulthood (b). Error bars denote standard deviations