From: Pulsatile flow drivers in brain parenchyma and perivascular spaces: a resistance network model study
Symbol | Description | Baseline value | Simulated range | Source |
---|---|---|---|---|
R _{ i} | PVS inner radius | 10 μm | 1–29 μm | [4, 13, 21] |
R _{ o} | PVS outer radius | 30 μm | 2–30 μm | [4] |
L_{PVS} | PVS segment length | 300 μm | – | [17, 21] |
L_{PCY} | Distance between vessels | 200 μm | – | [19] |
b | Wave amplitude | 0.25 μm | 0–0.37 μm | [13] |
f | Pulse frequency | 5 Hz | – | [14] |
– | Wave speed | 1 m/s | [24,25,26] | |
K | Hydraulic conductivity | 5.63 × 10^{−12} m^{2}/(Pa s) | 10^{2}–10^{11} μm^{3} s/kg | [27] |
μ | Dynamic viscosity | 0.9 × 10^{−3} Pa s | – | [28, 29] |
ρ | Interstitial fluid density | 993.2 kg/m^{3} | – | [30] |
ϕ | Porosity | 0.2 | [31] | |
D*^{b} | Solute diffusivity | – | 10^{1}–10^{3} μm^{2}/s | [31, 19] |
l ^{a} | Resistance length | 50; 100 μm | Model dependent | |
h | Resistance height | 100 μm | Model dependent | |
d | Resistance depth | 200 μm | Model dependent | |
R _{ i} ^{PCY} | Parenchyma inner radius | 10 μm | [4] | |
R _{ o} ^{PCY} | Parenchyma outer radius | 300 μm | Model dependent | |
η | Pore size | 60 nm | [32] | |
θ | Phase shift | 0 | 0–2π | Model dependent |
ξ | Pulsatility ratio | 0.80 | 0–1 | [13] |