Fig. 1
From: Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers
Microvesicle (MV) and exosome biogenesis in brain endothelial cells. Upon inflammatory stimuli, brain endothelial cells respond by releasing MVs (microvesicles) and exosomes into the bloodstream and/or in theory perivascularly. For exosomes, stimuli lead to internalization and formation of early endosomes that invaginate to create multivesicular bodies (MVB). For MVs, the vesicle is formed from budding of the plasma membrane.Vesicles are then released either into the blood or the brain parenchyma (theorized)