Fig. 3
From: Nimodipine treatment does not benefit juvenile ferrets with kaolin-induced hydrocephalus
Photomicrographs showing periventricular brain tissue after sacrifice (at age 52 days) of non-hydrocephalic and hydrocephalic ferret brains following a treatment period that lasted 14 days. Upper row (A) shows Ki67 immunostaining (positive nuclei of proliferating cells brown; with hematoxylin counterstain) at the dorsolateral angle of the frontal horn of the lateral ventricle (LV). In normal animals, the subventricular zone (SVZ) contains many proliferating cells whereas labeled cells are fewer in the hydrocephalic animals (see Table 1 for quantitative data). Lower row (B) shows GFAP immunostaining (positive astrocytes brown; with hematoxylin counterstain) in the corpus callosum (CC) above the LV. Astroglial hypertrophy is subtle and there are no obvious differences between the three hydrocephalic ferret treatment groups. Total magnification A—×400, B—×200; Scale bar = 100 μm