Fig. 1

T2-weighted magnetic resonance (MR) images of ferret brains depicting the frontal horns of the lateral ventricles in coronal slices. The pretreatment images were obtained at age 29 days (P29), 2 weeks after kaolin injection into the cisterna magna, and the posttreatment images were obtained at P52, after 2 weeks drug therapy. In non-hydrocephalic ferrets (top row) the ventricles are barely visible at both ages. In hydrocephalic ferrets of all three treatment groups, the ventricles expanded progressively during the treatment period. Increased signal intensity (due to increased water content) in the cerebral white matter was observed in all hydrocephalic treatment groups