Table 7 Brain development and long-term outcomes after IVH: research targets

Determining if PHH is associated with worse long-term neurodevelopmental, cognitive, and motor deficits compared to IVH and prematurity

Determining how damage to motile and primary cilia affects brain development

Understanding how cell proliferation from the ventricular and subventricular zones are altered after IVH

Identifying and targeting the mechanisms responsible for changes in cell proliferation

Linking neurodevelopmental and cognitive deficits to altered brain function

Developing targeted rehabilitation strategies for preterm neonates with IVH and PHH.

Determining mechanisms of tissue repair after PHH and how to enhance it

Determining the benefits of stem cell therapies on long-term outcomes

Determining impact of non-surgical interventions on long-term outcomes

Developing optimal psychometric and imaging-based instruments