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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Modeling and rescue of defective blood–brain barrier function of induced brain microvascular endothelial cells from childhood cerebral adrenoleukodystrophy patients

Fig. 5

Diblock copolymer treatment rescues defective barrier function of ccALD-iBMECs. a Chemical structures of polymers utilized for treatment. Poloxamer 188 is a triblock copolymer of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO); E182P16t is a diblock copolymer of PEO and PPO with a tert-butoxy end group on the PPO block. b Maximum TEER of WT1- and ccALD3-iBMECs treated with 1 mM of P188 or E182P16t. Treatment with 1 mM E182P16t resulted in improved ccALD-iBMEC barrier function. Data shown from four independent experiments with three biological replicates each (n = 12)

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