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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: Monoclonal antibody exposure in rat and cynomolgus monkey cerebrospinal fluid following systemic administration

Fig. 3

Serum and CSF concentration–time profiles of antibody A in adult male cynomolgus monkeys (a) after a single IV administration of 20 mg/kg (N = 4) or 100 mg/kg (N = 11). Left y-axes denote serum concentrations in μg/mL (open circle). Right y-axes denote CSF concentrations in ng/mL (open triangle). Data for each individual animal are plotted separately. Plots for observed (y-axis) versus predicted (x-axis) antibody A concentrations in serum (b) and CSF (c) are on log scales

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Fluids and Barriers of the CNS

ISSN: 2045-8118