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Fig. 1 | Fluids and Barriers of the CNS

Fig. 1

From: Monoclonal antibody exposure in rat and cynomolgus monkey cerebrospinal fluid following systemic administration

Fig. 1

Serum and CSF concentration–time profiles of antibodies A (10 mg/kg), B (10 mg/kg), C (20 mg/kg) and D (20 mg/kg) in adult Sprague–Dawley rats following single dose IV administration. For antibody A, perfused brain concentrations were also determined. Left y-axes denote antibody serum concentration in μg/mL (open circle). Right y-axes denote antibody CSF or brain concentrations in ng/mL (open triangle). Data for each individual animal are plotted separately

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Fluids and Barriers of the CNS

ISSN: 2045-8118