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Fig. 1 | Fluids and Barriers of the CNS

Fig. 1

From: Role of cationic drug-sensitive transport systems at the blood-cerebrospinal fluid barrier in para-tyramine elimination from rat brain

Fig. 1

In vivo analyses of p-TA elimination from rat brain or cerebrospinal fluid. a Time profile of [3H]p-TA remaining in the ipsilateral cerebrum after injection into rat cerebral cortex. A mixture of [3H]p-TA (120 nCi) and [14C]d-mannitol (6 nCi) dissolved in 0.5 μL buffer A was injected. The solid line was obtained by MULTI analysis. Each point represents the mean ± S.E.M. (n = 3). b Time profile of the residual CSF concentration (% dose × 100) of [3H]p-TA (open circles) and [14C]d-mannitol (closed squares) after administration into rat lateral ventricles and sampled from the cisterna magna. Buffer A containing [3H]p-TA (400 nCi/10 μL) and [14C]d-mannitol (5 nCi/10 μL) was injected into rat lateral ventricles. The solid line was obtained by MULTI analysis. Each point represents the mean ± S.E.M. (n = 3–4). *p < 0.05, significantly different from the value for [14C]d-mannitol. c Increase in the residual CSF concentration of [3H]p-TA at 2 min normalized to that of [14C]d-mannitol by simultaneous administration of unlabeled 75 mM p-TA. Each column represents the mean ± S.E.M. (n = 3–5). *p < 0.05, significantly different from the control

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