Do patients with schizophreniform and bipolar disorders show an intrathecal, polyspecific, antiviral immune response? A pilot study

Table 3 Characteristics of MRZR-positive psychiatric patients

	Syndrome	Neurological examination	MRZR	CSF	cMRI	EEG	Other immunological testing
Patient 1: 34 year, male	Schizo-depressive syndrome	No neurological signs	M: 1.6 (↑) R: ↔ Z: 1.9 (↑)	Cell count: 3 (↔) Alb_Q: 12 × 10⁻³ (↑)^a OCBs: negative	One unspecific white matter lesion right frontal	Normal	No antineuronal antibodies^b, no rheumatological antibodies^c, C3d slightly increased (9.6, reference < 9 mg/L). Increased anti-TG antibodies (150 IU/mL; reference < 115 IU/mL). Normal anti-TPO antibodies
Patient 2: 27 year, female	Schizo-depressive syndrome	No neurological signs	M: 1.7 (↑) R: ↔ Z: 1.5 (↑)	Cell count: 3 (↔) Alb_Q: 3 (↔) OCBs: negative	Normal	Normal	No antineuronal antibodies^b, no rheumatological antibodies^c, C3d normal. Normal anti-TPO- and -TG-antibodies

MRZR, MRZ reaction; M, measles; R, rubella; Z, varicella zoster; CSF, cerebrospinal fluid; cMRI, cerebral magnetic resonance imaging; EEG, electroencephalography; Alb_Q, albumin quotient; TG, thyroglobulin; TPO, thyroid peroxidase. ↔, normal; ↑, increased
^aAge dependent reference: 6.5 × 10⁻³
^bIncluding antibodies against intracellular onconeural antigens (Yo, Hu, CV2/CRMP5, Ri, Ma1/2, SOX1; measured in serum), against intracellular synaptic antigens (GAD, amphiphysin; in serum) and antibodies against neuronal cell surface antigens [NMDAR, AMPA-R, GABA-B-R, VGKC-complex (LGI1, Caspr2); in CSF]
^cAntinuclear, anti-neutrophil cytoplasmic, and antiphospholipid antibodies

ISSN: 2045-8118