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Fig. 1 | Fluids and Barriers of the CNS

Fig. 1

From: The opioid epidemic: a central role for the blood brain barrier in opioid analgesia and abuse

Fig. 1

Model of the of the neurovascular unit with a diagram indicating the relative brain penetrance of selected opioids. Endothelial cells surround the capillary lumen. P-Glycoprotein (green ovals) in the luminal membrane effluxes many types of opioids (red/blue circles) back into the circulation. Additional transporters (purple/orange) at the luminal membrane transport specific opioid analogs. In the methadone figure, the red and blue circles represent different methadone enantiomers

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