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Fig. 1 | Fluids and Barriers of the CNS

Fig. 1

From: Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017

Fig. 1

The enzyme luciferase produces light when the conversion of luciferin occurs. If a plasmid coding for luciferase is administered intravenously, no light signal can be detected (left mouse). The enzyme was degraded in the bloodstream. If the luciferase plasmid packaged in Engineered Protein Capsules (EPCs) is applied directly into the brain (intracerebral, i.c., middle mouse), a luminous signal can be detected there after administration of luciferin. This is also observed when the luciferase plasmid is packaged in EPCs and injected intravenously (i.v., right mouse)

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