Fig. 5

Individual plots of the concentrations of S-atenolol in plasma (a, d), blood dialysate (b, e), and brain dialysate (c, f) for Group 1 with 15-min fast i.v. infusion followed by 165-min slow i.v. infusion (a–c) and Group 2 with constant i.v. infusion for 180 min (d–f). Plots show observations (DV, solid circles), individual predictions (IPRED, solid lines), and population predictions (PRED, dash lines) from the model for each animal