Fig. 3
From: Revisiting atenolol as a low passive permeability marker
Individual concentration–time profiles of unbound S-atenolol in plasma (solid triangles and line) and brain (solid circles and lines) as well as total S-atenolol in plasma (open triangles and dashed lines) for (a) Group 1a and b (n = 9) with 15-min fast i.v. infusion followed by 165-min slow i.v. infusion, and (b) Group 2 (n = 4) with constant slow i.v. infusion for 180 min. For two rats, the Cu,brain data after 240 min are missing due to an LC–MS/MS malfunction during the analysis